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1

Cytotoxic immunotherapy strategies for cancer: Mechanisms and clinical development

Laura K. Aguilar, Brian W. Guzik, Estuardo Aguilar-Cordova

Journal:

Journal of Cellular Biochemistry

Year:

2011

Language:

english

File:

PDF, 293 KB

english, 2011

2

In Situ Gene Therapy for Adenocarcinoma of the Prostate: A Phase I Clinical Trial

Herman, James R., Adler, Howard L., Aguilar-Cordova, Estuardo, Rojas-Martinez, Augusto, Woo, Savio, Timme, Terry L., Wheeler, Thomas M., Thompson, Timothy C., Scardino, Peter T.

Journal:

Human Gene Therapy

Year:

1999

Language:

english

File:

PDF, 798 KB

english, 1999

3

923. Combining In Situ Gene Therapy with Radiotherapy and Hormonal Therapy in the Treatment of Stage D1 Prostate Cancer

Fujita, Tetsuo, Teh, Bin S., Timme, Terry L., Ayala, Gustavo, Mai, Wei-Yuan, Satoh, Takefumi, Kusaka, Nobuyuki, Naruishi, Koji, Tabata, Ken-ichi, Aguilar-Cordova, Estuardo, Wheeler, Thomas, Butler, E.

Journal:

Molecular Therapy

Year:

2006

Language:

english

File:

PDF, 151 KB

english, 2006

4

Phase I Study of Intrapleural Gene-Mediated Cytotoxic Immunotherapy in Patients with Malignant Pleural Effusion

Aggarwal, Charu, Haas, Andrew R., Metzger, Susan, Aguilar, Laura K., Aguilar-Cordova, Estuardo, Manzanera, Andrea G., Gómez-Hernández, Gregoria, Katz, Sharyn I., Alley, Evan W., Evans, Tracey L., Baum

Journal:

Molecular Therapy

Year:

2018

Language:

english

File:

PDF, 2.01 MB

english, 2018

5

Immunotherapy and gene therapy as novel treatments for cancer

Rangel-Sosa, Martha Montserrat, Aguilar-Córdova, Estuardo, Rojas-Martínez, Augusto

Journal:

Colombia médica

Year:

2017

File:

PDF, 1.47 MB

2017

6

Efficient ectopic gene expression targeting chick mesoderm

Kerby C. Oberg, Charmaine U. Pira, Jean-Pierre Revelli, Beate Ratz, Estuardo Aguilar-Cordova, Gregor Eichele

Journal:

Developmental Dynamics

Year:

2002

Language:

english

File:

PDF, 5.20 MB

english, 2002

7

Adenoviral gene transfer into dendritic cells efficiently amplifies the immune response to LMP2A antigen: A potential treatment strategy for Epstein-Barr virus–positive Hodgkin's lymphoma

Benedikt Gahn, Fernando Siller-Lopez, Angela D. Pirooz, Eric Yvon, Stephen Gottschalk, Richard Longnecker, Malcolm K. Brenner, Helen E. Heslop, Estuardo Aguilar-Cordova, Cliona M. Rooney

Journal:

International Journal of Cancer

Year:

2001

Language:

english

File:

PDF, 156 KB

english, 2001

8

Sustained Long-term Immune Responses Following In Situ Gene Therapy Combined with Radiotherapy and Hormonal Therapy in Prostate Cancer Patients

T. Fujita, B.S. Teh, T.L. Timme, W. Mai, T. Satoh, N. Kusaka, K. Naruishi, E.A. Fattah, E. Aguilar-Cordova, E. Butler, T.C. Thompson

Journal:

International Journal of Radiation Oncology*Biology*Physics

Year:

2005

Language:

english

File:

PDF, 74 KB

english, 2005

9

Sustained long-term immune responses after in situ gene therapy combined with radiotherapy and hormonal therapy in prostate cancer patients

Tetsuo Fujita, Bin S. Teh, Terry L. Timme, Wei-Yuan Mai, Takefumi Satoh, Nobuyuki Kusaka, Koji Naruishi, Elmoataz Abdel Fattah, Estuardo Aguilar-Cordova, E. Brian Butler, Timothy C. Thompson

Journal:

International Journal of Radiation Oncology*Biology*Physics

Year:

2006

Language:

english

File:

PDF, 205 KB

english, 2006

10

2193: Long-Term T Cell Activation Following Combined In Situ Gene Therapy and Intensity-Modulated Radiotherapy Compared to Gene Therapy as Mono-Therapy in Prostate Cancer Patients

T. Fujita, B.S. Teh, W. Mai, T. Satoh, K. Tabata, E. Aguilar-Cordova, B.J. Miles, D. Kadmon, E.B. Butler, T.C. Thompson

Journal:

International Journal of Radiation Oncology*Biology*Physics

Year:

2006

Language:

english

File:

PDF, 65 KB

english, 2006

11

2188: Long Term Biochemical Outcome of a Phase I-II Trial Evaluating Cytotoxic Immuno-Genetherapy in Combination With IMRT in Newly Diagnosed Prostate Cancer

B. Teh, W. Mai, J. Caillouet, G. Aguilar, E. Aguilar-Cordova, E. Butler

Journal:

International Journal of Radiation Oncology*Biology*Physics

Year:

2006

Language:

english

File:

PDF, 51 KB

english, 2006

12

Phase I/II trial evaluating combined radiotherapy and in-situ gene-therapy with or without hormonal therapy in the treatment of prostate cancer - a preliminary report

B.S Teh, E Aguilar-Cordova, K Kernan, B Miles, W.Y Mai, J Caillouet, C.C Chou, G Ayala, T Wheeler, M Shalev, D Kadmon, M Vlachaki, T Thompson, E.B Butler

Journal:

International Journal of Radiation Oncology*Biology*Physics

Year:

2000

Language:

english

File:

PDF, 222 KB

english, 2000

13

Enhanced therapeutic effect of mutiple injections of HSV-TK + GCV gene therapy in combination with ionizing radiation in a mouse mammary tumor model

Maria T Vlachaki, Madhu Chhikara, Laura Aguilar, Xiaohong Zhu, Kam J Chiu, Shiao Woo, Bin S Teh, Timothy C Thompson, E.Brian Butler, Estuardo Aguilar-Cordova

Journal:

International Journal of Radiation Oncology*Biology*Physics

Year:

2001

Language:

english

File:

PDF, 496 KB

english, 2001

14

Phase I/II trial evaluating combined radiotherapy and in situ gene therapy with or without hormonal therapy in the treatment of prostate cancer—A preliminary report

Bin S. Teh, Estuardo Aguilar-Cordova, Kenneth Kernen, Chieng-Chung Chou, Moshe Shalev, Maria T. Vlachaki, Brian Miles, Dov Kadmon, Wei-Yuan Mai, James Caillouet, Maria Davis, Gustavo Ayala, Thomas Whe

Journal:

International Journal of Radiation Oncology*Biology*Physics

Year:

2001

Language:

english

File:

PDF, 80 KB

english, 2001

15

Late toxicity of a phase I/II trial evaluating combined radiotherapy and in-situ gene-therapy with or without hormonal therapy in the treatment of prostate cancer

B.S Teh, E Aguilar-Cordova, L Aguilar, W Mai, J Caillouet, M Davis, M.T Vlachaki, D Kadmon, B Miles, G Ayala, T Thompson, E.B Butler

Journal:

International Journal of Radiation Oncology*Biology*Physics

Year:

2003

Language:

english

File:

PDF, 41 KB

english, 2003

16

Intravenous administration of replication-incompetent adenovirus to rhesus monkeys induces thrombocytopenia by increasing in vivo platelet clearance

N. Wolins, J. Lozier, T.L. Eggerman, E. Jones, E. Aguilar-Córdova, J. G. Vostal

Journal:

British Journal of Haematology

Year:

2003

Language:

english

File:

PDF, 142 KB

english, 2003

17

Histologic and immunohistochemical analysis of tissue response to adenovirus-mediated herpes simplex thymidine kinase gene therapy of ovarian cancer

A. Hasenburg, D. C. Fischer, X.-W. Tong, A. Rojas-Martinez, C. Nyberg-Hoffman, M. Orlowska-Volk, P. Kohlberger, R. H. Kaufman, I. Ramzy, E. Aguilar-Cordova, D. G. Kieback

Journal:

International Journal of Gynecological Cancer

Year:

2002

Language:

english

File:

PDF, 3.29 MB

english, 2002

18

Coinjection strategy for visual identification of transgenic mice

Paul A. Overbeek, Estuardo Aguilar-Cordova, Gerri Hanten, David L. Schaffner, Parul Patel, Russell M. Lebovitz, Michael W. Lieberman

Journal:

Transgenic Research

Year:

1991

Language:

english

File:

PDF, 2.72 MB

english, 1991

19

Suicide gene therapy for prostate cancer using a replication-deficient adenovirus containing the herpesvirus thymidine kinase gene

Moshe Shalev, Brian J. Miles, Timothy C. Thompson, Gustavo Ayala, Edward B. Butler, Estuardo Aguilar-Cordova, Dov Kadmon

Journal:

World Journal of Urology

Year:

2000

Language:

english

File:

PDF, 79 KB

english, 2000

20

Counterselection and Co-Delivery of Transposon and Transposase Functions forSleeping Beauty-Mediated Transposition in Cultured Mammalian Cells

Andrea D. Converse, Lalitha R. Belur, Jennifer L. Gori, Geyi Liu, Felipe Amaya, Estuardo Aguilar-Cordova, Perry B. Hackett, R. Scott McIvor

Journal:

Bioscience Reports

Year:

2004

Language:

english

File:

PDF, 433 KB

english, 2004

21

Phase I/II trial evaluating combined radiotherapy and in-situ gene therapy with or without hormonal therapy in the treatment of prostate cancer-an interim report on PSA response and biopsy data

B.S Teh, G.E Ayala, W Mai, M.T Vlachaki, J Caillouet, M Davis, M.M Wheeler, T.M Wheeler, B.J Miles, D Kadmon, L Aguilar-Cordova, S.Y Woo, L.S Carpenter, J.K Chiu, H.H Lu, T.C Thompson, E Aguilar-Cordo

Journal:

International Journal of Radiation Oncology*Biology*Physics

Year:

2002

Language:

english

File:

PDF, 21 KB

english, 2002

22

10.1038/11400

Aguilar-Cordova, Estuardo, Nyberg-Hoffman, Cassandra

Journal:

Nature Medicine

Year:

1999

Language:

english

File:

PDF, 322 KB

english, 1999

23

Vectorology recapitulates virology—will it capitulate oncology?

Aguilar-Cordova, Estaurdo

Journal:

Nature Biotechnology

Year:

2003

Language:

english

File:

PDF, 267 KB

english, 2003

24

Sensitivity and reproducibility in adenoviral infectious titer determination

Nyberg-Hoffman, Cassandra, Shabram, Paul, Li, Wei, Giroux, Daniel, Aguilar-Cordova, Estuardo

Journal:

Nature Medicine

Year:

1997

File:

PDF, 606 KB

1997

25

Thymidine kinase gene therapy with concomitant topotecan chemotherapy for recurrent ovarian cancer

Hasenburg, Annette, Tong, Xiao-Wen, Rojas-Martinez, Augusto, Nyberg-Hoffman, Cassandra, Kieback, Christina C, Kaplan, Alan, Kaufman, Raymond H, Ramzy, Ibrahim, Aguilar-Cordova, Estuardo, Kieback, Dirk

Journal:

Cancer Gene Therapy

Year:

2000

Language:

english

File:

PDF, 126 KB

english, 2000

26

Coxsackievirus–adenovirus receptor expression in ovarian cancer cell lines is associated with increased adenovirus transduction efficiency and transgene expression

You, Zongbing, Fischer, Dagmar C, Tong, Xiaowen, Hasenburg, Annette, Aguilar-Cordova, Estuardo, Kieback, Dirk G

Journal:

Cancer Gene Therapy

Year:

2001

Language:

english

File:

PDF, 1.77 MB

english, 2001

27

Intraperitoneal adenovirus-mediated suicide gene therapy in combination with either topotecan or paclitaxel in nude mice with human ovarian cancer

Kieback, Dirk G, Fischer, Dagmar-Christiane, Engehausen, Dirk G, Sauerbrei, Willi, Oehler, Martin K, Tong, Xiao-Wen, Aguilar-Cordova, Estuardo

Journal:

Cancer Gene Therapy

Year:

2002

Language:

english

File:

PDF, 191 KB

english, 2002

28

Neurotoxicity of intracerebral injection of a replication-defective adenoviral vector in a semipermissive species (cotton rat)

Shine, H D, Wyde, P R, Aguilar-Cordova, E, Chen, S-H, Woo, S L C, Grossman, R G, Goodman, J C

Journal:

Year:

1997

Language:

english

File:

PDF, 558 KB

english, 1997

29

Gene therapy for prostate cancer: toxicological profile of four HSV-tk transducing adenoviral vectors regulated by different promoters

Ebara, S, Shimura, S, Nasu, Y, Kaku, H, Kumon, H, Yang, G, Wang, J, Timme, T L, Aguilar-Cordova, E, Thompson, T C

Journal:

Prostate Cancer and Prostatic Diseases

Year:

2002

Language:

english

File:

PDF, 576 KB

english, 2002

30

Evolution of a Gene Therapy Clinical Trial

Laura K. Aguilar, Estuardo Aguilar-Cordova

Journal:

Journal of Neuro-Oncology

Year:

2003

Language:

english

File:

PDF, 71 KB

english, 2003

31

The Combination of Adenoviral HSV TK Gene Therapy and Radiation is Effective in Athymic Mouse Glioblastoma Xenografts without Increasing Toxic Side Effects

Ulf Nestler, Hiroaki Wakimoto, Fernando Siller-Lopez, Laura K. Aguilar, Arnab Chakravarti, Alona Muzikansky, Anat Stemmer-Rachamimov, E. Antonio Chiocca, Estuardo Aguilar-Cordova, Fred H. Hochberg

Journal:

Journal of Neuro-Oncology

Year:

2004

Language:

english

File:

PDF, 199 KB

english, 2004

32

Adenovirus-Mediated Thymidine Kinase Gene Therapy in Combination with Topotecan for Patients with Recurrent Ovarian Cancer: 2.5-Year Follow-Up

A. Hasenburg, X.-W. Tong, D.C. Fischer, Ph.D., A. Rojas-Martinez, C. Nyberg-Hoffman, A.L. Kaplan, R.H. Kaufman, I. Ramzy, E. Aguilar-Cordova, D.G. Kieback

Journal:

Gynecologic Oncology

Year:

2001

Language:

english

File:

PDF, 55 KB

english, 2001

33

Virus Specific Immune Responses after Human Neoadjuvant Adenovirus-mediated Suicide Gene Therapy for Prostate Cancer

R.R.M. van der Linden, B.L. Haagmans, P. Mongiat-Artus, G.J. van Doornum, R. Kraaij, D. Kadmon, E. Aguilar-Cordova, A.D.M.E. Osterhaus, T.H. van der Kwast, C.H. Bangma

Journal:

European Urology

Year:

2005

Language:

english

File:

PDF, 524 KB

english, 2005

34

Metastatic and Nonmetastatic Models of Retinoblastoma

Patricia Chévez-Barrios, Mary Y. Hurwitz, Kathryn Louie, Karen T. Marcus, Vien N. Holcombe, Pamela Schafer, C. Estuardo Aguilar-Cordova, Richard L. Hurwitz

Journal:

The American Journal of Pathology

Year:

2000

Language:

english

File:

PDF, 986 KB

english, 2000

35

Cytopathic effect of in situ gene therapy in prostate cancer

Gustavo Ayala, Thomas M. Wheeler, Moshe Shalev, Timothy C. Thompson, Brian Miles, Estuardo Aguilar-Cordova, Subhendu Chakraborty, Dov Kadmon

Journal:

Human Pathology

Year:

2000

Language:

english

File:

PDF, 420 KB

english, 2000

36

Truncated active matrix metalloproteinase-8 gene expression in HepG2 cells is active against native type I collagen

Fernando Siller-López, Jesus García-Bañuelos, Karen A Hasty, Jorge Segura, Martha Ramos-Márquez, M Walid Qoronfleh, Estuardo Aguilar-Cordova, Juan Armendáriz-Borunda

Journal:

Journal of Hepatology

Year:

2000

Language:

english

File:

PDF, 805 KB

english, 2000

37

Treatment with human metalloproteinase-8 gene delivery ameliorates experimental rat liver cirrhosis resembling alcoholic human disease

Fernando Siller, Silvia Salgado, Jesus Garcia, Jose M. Vera, Alejandra Miranda, Guillermo Grijalva, Javier Galvez, Estuardo Aguilar-Cordova, Juan Armendariz-Borunda

Journal:

Journal of Hepatology

Year:

2002

Language:

english

File:

PDF, 175 KB

english, 2002

38

Human UPA gene therapy as a co-adyuvant element of bilio-digestive anastomosis in the treatment of secondary biliary cirrhosis

Juan Armendariz-Borunda, Alejandra Miranda, Silvia Salgado, Miriam Bueno, Jose Vera, Estuardo Aguilar-Cordova

Journal:

Journal of Hepatology

Year:

2002

Language:

english

File:

PDF, 116 KB

english, 2002

39

The Spectrum of Vaccine Therapies for Patients With Glioblastoma Multiforme

Aguilar, Laura K., Arvizu, Mariel, Aguilar-Cordova, Estuardo, Chiocca, E. Antonio

Journal:

Current Treatment Options in Oncology

Year:

2012

Language:

english

File:

PDF, 286 KB

english, 2012

40

885 Metalloproteinase-8 gene delivery up-regulates MMP-2, MMP-3 and induces cell proliferation in experimental liver cirrhosis

Juan Armendariz-Borunda, Fernando Siller-Lopez, Jesus Garcia, Ana Sandoval, Silvia Salgado, Adriana Salazar, Estuardo Aguilar-Cordova

Journal:

Year:

2003

Language:

english

File:

PDF, 135 KB

english, 2003

41

Treatment with human metalloproteinase-8 gene delivery ameliorates experimental rat liver cirrhosis

Fernando Siller-López, Ana Sandoval, Silvia Salgado, Adriana Salazar, Miriam Bueno, Jesus Garcia, Jose Vera, Javier Gálvez, Iván Hernández, Martha Ramos, Estuardo Aguilar-Cordova, Juan Armendariz-Boru

Journal:

Gastroenterology

Year:

2004

Language:

english

File:

PDF, 802 KB

english, 2004

42

SUICIDE GENE THERAPY TOXICITY AFTER MULTIPLE AND REPEAT INJECTIONS IN PATIENTS WITH LOCALIZED PROSTATE CANCER

SHALEV, MOSHE, KADMON, DOV, TEH, BIN S., BUTLER, EDWARD B., AGUILAR-CORDOVA, ESTUARDO, THOMPSON, TIMOTHY C., HERMAN, JAMES R., ADLER, HOWARD L., SCARDINO, PETER T., MILES, BRIAN J.

Journal:

The Journal of Urology

Year:

2000

Language:

english

File:

PDF, 64 KB

english, 2000

43

TAK, an HIV Tat-Associated Kinase, is a Member of the Cyclin-Dependent Family of Protein Kinases and is Induced by Activation of Peripheral Blood Lymphocytes and Differentiation of Promonocytic Cell Lines

Xinzhen Yang, Moses O. Gold, Derek Ng Tang, Dorothy E. Lewis, Estuardo Aguilar-Cordova, Andrew P. Rice and Christine H. Herrmann

Journal:

Proceedings of the National Academy of Sciences

Year:

1997

Language:

english

File:

PDF, 1.58 MB

english, 1997

44

Hepatocyte Gene Therapy in a Large Animal: A Neonatal Bovine Model of Citrullinemia

Brendan Lee, Julie A. Dennis, Peter J. Healy, Benjamin Mull, Lucio Pastore, Hung Yu, Estuardo Aguilar-Cordova, William O'Brien, Peter Reeds and Arthur L. Beaudet

Journal:

Proceedings of the National Academy of Sciences

Year:

1999

Language:

english

File:

PDF, 1.64 MB

english, 1999

45

Administration of Helper-Dependent Adenoviral Vectors and Sequential Delivery of Different Vector Serotype for Long-Term Liver-Directed Gene Transfer in Baboons

Núria Morral, Wanda O'Neal, Karen Rice, Michele Leland, Johanne Kaplan, Pedro A. Piedra, Heshan Zhou, Robin J. Parks, Rizwan Velji, Estuardo Aguilar-Córdova, Samuel Wadsworth, Frank L. Graham, Stefan

Journal:

Proceedings of the National Academy of Sciences

Year:

1999

Language:

english

File:

PDF, 1.04 MB

english, 1999

46

Suicide Gene Therapy for Treatment of Retinoblastoma in a Murine Model

Hurwitz, Mary Y., Marcus, Karen T., Chevez-Barrios, Patricia, Louie, Kathryn, Aguilar-Cordova, Estuardo, Hurwitz, Richard L.

Journal:

Human Gene Therapy

Year:

1999

Language:

english

File:

PDF, 707 KB

english, 1999

47

Reporting Adverse Events in Gene Therapy Studies

Dr Bambi J. Grilley,Laura K. Aguilar,Estuardo Aguilar-Cordova

Journal:

Year:

2000

Language:

english

File:

PDF, 170 KB

english, 2000

48

Prostate-Specific Antigen Response and Systemic T Cell Activation After In Situ Gene Therapy in Prostate Cancer Patients Failing Radiotherapy

Miles, Brian J., Shalev, Moshe, Aguilar-Cordova, Estuardo, Timme, Terry L., Lee, Hon-Man, Yang, Guang, Adler, Howard L., Kernen, Kenneth, Pramudji, Christina K., Satoh, Takefumi, Gdor, Yehoshua, Ren,

Journal:

Human Gene Therapy

Year:

2001

Language:

english

File:

PDF, 782 KB

english, 2001

49

A Sensitive Reporter Cell Line for HIV-1 tat Activity, HIV-1 Inhibitors, and T Cell Activation Effects

AGUILAR-CORDOVA, ESTUARDO, CHINEN, JAVIER, DONEHOWER, LARRY, LEWIS, DOROTHY E., BELMONT, JOHN W.

Journal:

AIDS Research and Human Retroviruses

Year:

1994

Language:

english

File:

PDF, 3.50 MB

english, 1994

50

Toxicological Comparison of E2a-Deleted and First-Generation Adenoviral Vectors Expressing α 1 -Antitrypsin after Systemic Delivery

O'Neal, Wanda K., Zhou, Heshan, Morral, Núria, Aguilar-Cordova, Estuardo, Pestaner, Joseph, Langston, Claire, Mull, Benjamin, Wang, Yufen, Beaudet, Arthur L., Lee, Brendan

Journal:

Human Gene Therapy

Year:

1998

Language:

english

File:

PDF, 4.88 MB

english, 1998